If you are on a Windows machine running 8.1 (and maybe previous versions) and you accidentally press the windows key + enter, you’ll start up Narrator, an accessibility program that reads everything on the screen to you.
To turn it off, press caps lock+escape.
It doesn’t appear that you can turn off the keyboard shortcut :(.
Found here.
You can use the “Ease of Access” feature to hack into some Windows-based kiosks; just hit the shift key 5 times in a row to turn on “Sticky Keys”